A prudent path forward for genomic engineering and germline gene modification
By D. Baltimore, P. Berg, M. Botchan, D. Carroll, R. A. Charo, George M. Church, J. Corn, G. Daley, Jennifer A. Doudna, M. Fenner and 8 more. Science, 2015
625 citations recorded by the source corpus.
A framework for open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome is urgently needed Genome engineering technology offers unparalleled potential for modifying human and nonhuman genomes. In humans, it holds the promise of curing genetic disease, while in other organisms it provides methods to reshape the biosphere for the benefit of the environment and human societies. However, with such enormous opportunities come unknown risks to human health and well-being. In January, a group of interested stakeholders met in Napa, California (1), to discuss the scientific, medical, legal, and ethical implications of these new prospects for genome biology. The goal was to initiate an informed discussion of the uses of genome engineering technology, and to identify those areas where action is essential to prepare for future developments. The meeting identified immediate steps to take toward ensuring that the application of genome engineering technology is performed safely and ethically.
Subfields: Business and International Management, Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5e218166d49017d40c651669c9e130e6071e1be4
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Citations in the corpus
- CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes (2015, background): “In particular, off-target effect of CRISPR/ Cas9 should be investigated thoroughly before any clinical application (Baltimore et al., 2015; Cyranoski, 2015; Lanphier et al., 2015).”
- Gene therapy clinical trials worldwide to 2017: An update (2018, background): “There have also been reports of the use of CRISPR/Cas9 to edit human embryos initially in China and more recently in the USA,(109-111) sparking debate on the ethics of introducing heritable changes with unknown effects on future generations.(112-116)”
- Tropicalisation of temperate reefs: Implications for ecosystem functions and management actions (2019, background): “…technology development of stem‐cell therapies or more recently, CRISPER‐based approaches, is happening well in advance of community understanding or acceptance of the desirability or ethics of these technologies (Baltimore et al., 2015), contributing to disruption in uptake and community anxiety.”