Function and information content of DNA methylation
By Dirk Schübeler. 2015
1,849 citations recorded by the source corpus.
Subfields: Molecular Biology
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In Molecular Biology
- Benjamin L. Ebert
- Siddhartha Jaiswal
- Andrea A. Baccarelli
- Andrew E. Teschendorff
- Dirk Schübeler
- Steve Horvath
- Stephan Beck
- Leonard C. Schalkwyk
Citations in the corpus
- Impact of cytosine methylation on DNA binding specificities of human transcription factors (2017, background): “This is accomplished by the methyltransferase DNMT1, which associates with the DNA replication fork, methylating the newly synthesized DNA strand at positions where its template strand is methylated (7).”
- Macrophages in immunoregulation and therapeutics (2023, background): “DNA Methyl marks are catalytically added by DNA methyltransferases (DNMTs) can be passively or actively removed by the ten-eleven translocation (TET) DNA dioxygenases.(225) DNMT1 is a maintenance methyltransferase and participates in the regulation of histone modifications.”
- Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials (2019, background): “family via the transfer of a methyl group from S-adenosyl-Lmethionine (SAM) to cytosine.(44) There are five members of the DNMT family: DNMT1, DNMT2, DNMT3a, DNMT3b, and DNMT3L.”
- Clonal hematopoiesis in human aging and disease (2019, positive): “DNMT3A is one of the two enzymes responsible for de novo methylation of the fifth position in cytosine bases of DNA, a mark that is thought to influence gene expression (47, 48).”
- DNA methylation aging clocks: challenges and recommendations (2019, background): “Also, what changes are occurring prior to observable age-related changes, such as up-regulation of trans-acting TFs.”