Non-adherence to highly active antiretroviral therapy predicts progression to AIDS.

By D. Bangsberg, S. Perry, E. Charlebois, R. Clark, Marjorie Roberston, A. Zolopa, A. Moss. AIDS (London), 2001

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Medication adherence in HIV-infected adults: effect of patient age, cognitive status, and substance abuse (2004, background): “papers have found that such high adherence rates are necessary to achieve optimal viral suppression [4], and slow the rate at which drug-resistant strains of the virus emerge [6], others have failed to find differences in disease progression between patients who only adhere to 70–90% of doses compar”
Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders (2011, positive): “Although antiretroviral therapy (ART) has dramatically reduced morbidity and mortality for people living with HIV/AIDS, incomplete treatment adherence is the major cause of treatment failure, development of drug resistance, HIV disease progression, and death [1–5].”