Scavenger receptors in homeostasis and immunity

By Johnathan Canton, D. Neculai, S. Grinstein. Nature reviews. Immunology, 2013

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Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, positive): “Scavenger receptors comprise a family of receptors that broadly recognize modified lowdensity lipoproteins, polyanions, endogeneous proteins, as well as conserved microbial structures and are important for clearing foreign particles, pathogens, and apoptotic cells from the body [147].”
Phagocytosis: An Immunobiologic Process. (2016, background): “Recent structural studies on SR-B, a CD36-related family member, revealed that apoprotein ligands bind to receptor helical bundles, whereas their exofacial domains form a channel through which lipids such as cholesterol are translocated to the membrane bilayer (Canton et al., 2013).”
Alternatively activated microglia and macrophages in the central nervous system. (2015, background): “…al. (2012) CD36 Surface receptor Scavenger receptor, forms a complex with toll-like receptors to potentiate production of cytokines Yes Yes Yes Yes Canton et al. (2013) CD68 Surface receptor Scavenger receptor Yes Yes Yes Yes Perego et al. (2011) CD86 Surface receptor Surface receptor, also known…”
The delivery of therapeutic oligonucleotides (2016, background): “This cohort of transmembrane receptors constitutes a functional family rather than one demarcated by common sequence or structure (59,113).”