Neural ensemble dynamics underlying a long-term associative memory
By Benjamin F. Grewe, Jan Gründemann, Lacey J. Kitch, J. Lecoq, Jones G. Parker, Jesse D. Marshall, Margaret C. Larkin, Pablo E. Jercog, Francois Grenier, Jin Zhong Li and 2 more. Nature, 2017
301 citations recorded by the source corpus.
The brain’s ability to associate different stimuli is vital for long-term memory, but how neural ensembles encode associative memories is unknown. Here we studied how cell ensembles in the basal and lateral amygdala encode associations between conditioned and unconditioned stimuli (CS and US, respectively). Using a miniature fluorescence microscope, we tracked the Ca2+ dynamics of ensembles of amygdalar neurons during fear learning and extinction over 6 days in behaving mice. Fear conditioning induced both up- and down-regulation of individual cells’ CS-evoked responses. This bi-directional plasticity mainly occurred after conditioning, and reshaped the neural ensemble representation of the CS to become more similar to the US representation. During extinction training with repetitive CS presentations, the CS representation became more distinctive without reverting to its original form. Throughout the experiments, the strength of the ensemble-encoded CS–US association predicted the level of behavioural conditioning in each mouse. These findings support a supervised learning model in which activation of the US representation guides the transformation of the CS representation.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/5d19b3730ec6a10e6837af321875f8df39605617
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
Citations in the corpus
- Tracking the Same Neurons across Multiple Days in Ca2+ Imaging Data (2017, background): “Thus, the set of detected cells can differ between sessions (Ziv et al., 2013; Resendez et al., 2016; Grewe et al., 2017; Xia et al., 2017), and a one-toone mapping of neural identity across sessions is typically not attainable.”