Topological mirror images in protein structure computation: An underestimated problem

By A. Pastore, R. Atkinson, V. Saudek, Robert J.P. Williams. 1991

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Joe G. Greener
2. Shaun M. Kandathil
3. Yang Zhang
4. David T. Jones
5. Robin Pearce
6. Jeffrey Skolnick
7. Chengxin Zhang
8. Angel R. Ortiz

Citations in the corpus

• Deep learning extends de novo protein modelling coverage of genomes using iteratively predicted structural constraints (2018, background): “They are also susceptible to producing mirrored topologies where the secondary structures have the correct handedness, but the overall 3-D packing of the secondary structural elements is itself a mirror of the native structure ​[12,13]​.”
• MONSSTER: a method for folding globular proteins with a small number of distance restraints. (1997, background): “(Pastore et al., 1991) Helices, when present, are right-handed in both the correct and mirror-image topology.”