Predictors of outcome in severe, asymptomatic aortic stenosis.

By R. Rosenhek, T. Binder, G. Porenta, I. Lang, G. Christ, M. Schemper, G. Maurer, Helmut Baumgartner. New England Journal of Medicine, 2000

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How researchers see this paper

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Calcific aortic stenosis: a disease of the valve and the myocardium. (2012, neutral): “development of symptoms and adverse events (24).”
[2017 ESC/EACTS Guidelines for the management of valvular heart disease]. (2017, background): “support the general recommendation of early SAVR, even in patients with asymptomatic very severe aortic stenosis.(92,106) The decision to operate on asymptomatic patients requires careful weighing of the benefits against the risks.”
Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice. (2009, neutral): “The degree of valve calcification is a predictor of clinical outcome.(4,7) Rheumatic AS is characterized by commisural fusion, resulting in a triangular systolic orifice, with thickening and calcification most prominent along the edges of the cusps.”
Guidelines on the management of valvular heart disease The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (2006, background): “• Echocardiography: valve calcification, peak aortic jet velocity [88– 91], LVEF [90], rate of haemodynamic progression [89], increase in gradient with exercise [80, 81], excessive LV hypertrophy [92],”
2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. (2014, background): “pressure gradient 40 mm Hg or higher (108,138).”