Natural selection has driven population differentiation in modern humans

By L. Barreiro, Guillaume Laval, H. Quach, E. Patin, L. Quintana-Murci. Nature Genetics, 2008

634 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5cb06ec52fbd31b229791f87fcf99b2cc0198251

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Citations in the corpus

Signals of recent positive selection in a worldwide sample of human populations. (2009, background): “Recently, a number of analytical techniques have been developed to identify signals of recent positive selection on a genome-wide scale and applied to polymorphism data from several human populations (Kelley et al. 2006; Voight et al. 2006; Wang et al. 2006; Sabeti et al. 2007; Williamson et al. 200”
Integrative Annotation of Variants from 1092 Humans: Application to Cancer Genomics (2013, background): “In this respect, our results are consistent with previous studies for missense SNPs: Overall they are under strong negative selection, but a small group of them have been targets of positive selection (36).”
Ancestry informative markers for fine-scale individual assignment to worldwide populations (2010, positive): “In fact, population differentiation has been considered as an indication of selective pressure, and several genome scans for natural selection were based on the identification of loci that appear as outliers in empirical distributions of genotypic patterns (see [49, 50, 51, 6, 52, 53] among others).”
The Nature of Race (2015, neutral): “Table 2 of Barreiro et al. (2008).”
Pitfalls of predicting complex traits from SNPs (2013, background): “The larger the effect of a SNP on a fitness the lower the frequencies of the causal alleles are expected to be 22, 23 .”
Estimating and interpreting FST: The impact of rare variants (2013, background): “For example, selection can result in differences between FST estimated on genic and nongenic SNPs (Clark et al. 2005; Barreiro et al. 2008; Hernandez et al. 2011); complex demography can cause FST to vary with SNP allele frequency (Schaffner et al.”
The Genetics of Human Adaptation: Hard Sweeps, Soft Sweeps, and Polygenic Adaptation (2010, positive): “These include signals of partial sweeps [20], reduced diversity at putatively neutral sites [28,29] and an excess of SNPs with extreme population differentiation (high FST) within genes (Figure 1A) [30].”