Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

By M. Powner, Béatrice Gerland, J. Sutherland. Nature, 2009

1,196 citations recorded by the source corpus.

Subfields: Astronomy and Astrophysics, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5c9a4dc5ebbb6438b78a043306e3773f81360887

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Astronomy and Astrophysics

1. D. Wilner
2. S. Andrews
3. E. Bergin
4. C. Qi
5. K. Oberg
6. T. Birnstiel
7. R. Teague
8. L. P'erez

In Materials Chemistry

1. N. Kitadai
2. S. Maruyama
3. K. Oberg
4. Dejan-Krešimir Bučar

In Molecular Biology

1. N. Kitadai
2. S. Maruyama
3. S. Islam
4. J. Sutherland
5. J. Szostak
6. J. Baross
7. M. Powner
8. Dejan-Krešimir Bučar

Citations in the corpus

• Origins of building blocks of life: A review (2017, methodology): “Irradiation of this molecule with UV light (254 nm, 80 h) converts it to b-ribourydine20,30-cyclic phosphate (Powner et al., 2009).”
• Molecules with ALMA at Planet-forming Scales (MAPS). I. Program Overview and Highlights (2021, background): “While we do not know how life originated on Earth, nitriles and other small, reactive organics are implicated in several origins of life scenarios (Powner et al. 2009; Patel et al. 2015; Pearce et al. 2017) and their distributions in the inner regions of disks are of special interest.”
• When Did Life Likely Emerge on Earth in an RNA‐First Process? (2019, neutral): “Adapted from Powner et al. (2009)[4a] and Becker et al. (2016).”
• Welcome Home, Systems Chemists! (2010, background): “While the autocatalytic nature in the early stage of the reaction is reasonably understood, recipes for the selective harvesting of prebiotic “target molecules” such as ribose (needed for RNA, or perhaps not, see [48]) at the late “library state” of reaction, so far have not been based on autocataly”
• Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism (2015, background): “However, after the addition of copper(II) chloride, hydrogen cyanide (11) and acetylene (32) to a Nieuwland catalyst, we could not detect any free cyanoacetylene (6).”
• The eightfold path to non-enzymatic RNA replication (2012, background): “Other reagents such as cyanoimidazole, di-imidazole imine, carbonyl-diimidazole, and cyanoacetylene [4] are even more reactive and tend to alkylate mildly nucleophilic groups on both the nucleobases and sugars of both substrates and templates.”
• The Surface UV Environment on Planets Orbiting M Dwarfs: Implications for Prebiotic Chemistry and the Need for Experimental Follow-up (2017, background): “…pathway will dominatethe former, and the sugar synthesis pathway will not proceed.22 Similarly, the efficacy of UV light at selecting and amplifying the population of biogenic ribonucleotides and generating uridine from cytidine in Powner et al. (2009) will be functions of the irradiation level.”
• The pH of Enceladus’ ocean (2015, background): “Alternatively, life may have never started on Enceladus if a lower pH, an atmosphere (Miller, 1953), plate tectonics, or access to sunlight or dry land (Powner et al., 2009) are necessary.”
• Prebiotic selection and assembly of proteinogenic amino acids and natural nucleotides from complex mixtures (2017, background): “However, remarkably, incubation of dihydroxyacetone (2q) with either 2-aminothiazole (7) or β-mercaptoacetaldehyde (9a) and cyanamide (3) (to effect in situ synthesis of 2-aminothiazole (7)) delivered glyceraldehyde (2b) aminal rac-8b in up to 87% yield (Fig.”