Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL.

By B. He, Weifeng Xu, Paul A. Santini, A. Polydorides, A. Chiu, Jeannelyn S. Estrella, Meimei Shan, A. Chadburn, V. Villanacci, A. Plebani and 3 more. Immunity, 2007

769 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/5c6aed80e4080b61dd308a93890b029a1abf6c46

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In Immunology

1. Dan R. Littman
2. F. Mackay
3. Olivier Schwartz
4. B. B. Finlay
5. A. Cerutti
6. Jeffrey I. Gordon
7. M. Miyara
8. R. Sartor

Citations in the corpus

• The regulation of IgA class switching (2008, background): “IgA2 is particularly abundant at sites colonized by a large microbiota, including the distal intestinal tract and the urogenital trac”
• Cracking the BAFF code (2009, background): “Furthermore, in humans, intestinal epithelial cells produce APRIL in response to TLR activation, which drives local TACI-mediated class switching from IgA1 to IgA2 (Ref”
• IgA dominates the early neutralizing antibody response to SARS-CoV-2 (2020, background): “0) Chronic medical illness Coronary heart disease or cardiovascular disease 37 (27) Diabetes 43 (32) Body mass index (kg/m(2)) underweight (≤18.”