Is the failing heart energy starved? On using chemical energy to support cardiac function.

By J. Ingwall, R. Weiss. Circulation Research, 2004

630 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Electrical and Electronic Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5c5c935a6dc2d39a34ac2266f5bb5ede2b12812d

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In Cardiology and Cardiovascular Medicine

1. Rong Tian
2. Christoph Handschin
3. Bo Zhou
4. B. Spiegelman
5. Suneet N. Purohit
6. Stephen C. Kolwicz

In Electrical and Electronic Engineering

1. Rong Tian

In Molecular Biology

1. Christoph Handschin
2. B. Spiegelman
3. Jiandie D. Lin
4. Rong Tian
5. R. Bassel-Duby
6. C. Deng
7. A. Chicco
8. Toren Finkel

Citations in the corpus

• Cardiac Metabolism and Its Interactions with Contraction, Growth, and Survival of the Cardiomyocte (2013, result): “The PCr/ATP ratio has been shown to be a superior predictor of mortality as compared with ejection fraction (EF) in patients with heart failure,(86) which is in agreement with the long-standing hypothesis that energy starvation contributes to the pathogenesis and progression of heart failure (see re”
• Role of cardiolipin alterations in mitochondrial dysfunction and disease. (2007, background): “Alterations in mitochondrial energy metabolism have been widely observed in human and animal models of heart failure (HF) and are hypothesized to play an important role in the development and/or progression of the disease (63, 182).”
• A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis (2008, background): “It should be noted, however, that in organs such as the heart, concentrations of ATP are normally in the millimolar range (19).”
• Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle (2005, background): “In a given day, the heart can consume approximately ten times its own weight in ATP (Ingwall, 2003; Ingwall and Weiss, 2004).”
• Mitochondrial dysfunction in pathophysiology of heart failure (2018, background): “One interpretation of this observation is that myocardial energy status is sustained by “adaptive” mechanisms mobilized during the progression of heart failure (46, 47).”