Nramp5 Is a Major Transporter Responsible for Manganese and Cadmium Uptake in Rice[C][W]

By Akimasa Sasaki, Naoki Yamaji, Kengo Yokosho, J. Ma. The Plant Cell, 2012

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Plant abiotic stress response and nutrient use efficiency (2020, background): “Knockout of OsNRAMP5 could decrease grain Cd concentrations by up to 90%, though Mn, Fe and Zn were also significantly decreased (Ishikawa et al., 2012; Sasaki et al., 2012).”
Heavy Metal Tolerance in Plants: Role of Transcriptomics, Proteomics, Metabolomics, and Ionomics (2016, background): “…new Nramp5 belonging to rice (Os Nramp5) has been characterized, which is responsible for accumulation of Mn in rice and has been reported to encode proteins localized on plasmamembrane, thus suggesting that Nramp5 is a major transporter responsible for transport of Mn and Cd (Sasaki et al., 2012).”
How Does Contamination of Rice Soils with Cd and Zn Cause High Incidence of Human Cd Disease in Subsistence Rice Farmers (2015, background): “Whether high soil solution Mn represses expression of NRAMP5 has not been clarified to date although the gene was reported to be constitutively expressed [54].”