Nano-graphene oxide for cellular imaging and drug delivery

By Xiaoming Sun, Zhuang Liu, Kevin D. Welsher, J. Robinson, Andrew P. Goodwin, S. Zaric, Hongjie Dai. Nano Reseach, 2008

3,130 citations recorded by the source corpus.

Two-dimensional graphene offers interesting electronic, thermal, and mechanical properties that are currently being explored for advanced electronics, membranes, and composites. Here we synthesize and explore the biological applications of nano-graphene oxide (NGO), i.e., single-layer graphene oxide sheets down to a few nanometers in lateral width. We develop functionalization chemistry in order to impart solubility and compatibility of NGO in biological environments. We obtain size separated pegylated NGO sheets that are soluble in buffers and serum without agglomeration. The NGO sheets are found to be photoluminescent in the visible and infrared regions. The intrinsic photoluminescence (PL) of NGO is used for live cell imaging in the near-infrared (NIR) with little background. We found that simple physisorption via π-stacking can be used for loading doxorubicin, a widely used cancer drug onto NGO functionalized with antibody for selective killing of cancer cells in vitro. Owing to its small size, intrinsic optical properties, large specific surface area, low cost, and useful non-covalent interactions with aromatic drug molecules, NGO is a promising new material for biological and medical applications.

Subfields: Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/5bda6d1af13302a6ed9873fd680015055fc2e5ea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Hongjie Dai
2. Zhuang Liu
3. M. Prato
4. Zhijun Zhang
5. Liming Zhang
6. He Shen
7. Min Liu
8. K. Loh

In Materials Chemistry

1. Zhipei Sun
2. Tawfique Hasan
3. Zhuang Liu
4. Hongjie Dai
5. Andrea C. Ferrari
6. Francesco Bonaccorso
7. K. Loh
8. M. Chhowalla

Citations in the corpus

• Graphene-based antibacterial paper. (2010, methodology): “Very recently, graphene paper has been found to be a biocompatible substrate for adhesion and proliferation of L-929 cells,(20) neuroendocrine PC12 cells, oligodendroglia cells, and osteoblasts,(34) and graphene oxide has been employed as an effective nanocargo to deliver water-insoluble drugs into ”
• Oxidative stress-mediated antibacterial activity of graphene oxide and reduced graphene oxide in Pseudomonas aeruginosa (2012, methodology): “PEGylated GO in a physiological solution has been employed in cell imaging and drug delivery.(16,17) Wang et al(18) have suggested that dose- and time-dependent cytotoxicity of GO, which can enter the cytoplasm and nucleus, decreases cell adhesion and induces apoptosis.”