Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives.

By Raghavendra C. Mundargi, V. Babu, V. Rangaswamy, P. Patel, T. Aminabhavi. Journal of Controlled Release, 2008

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Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier (2011, background): “Additionally, it is possible to tune the overall physical properties of the polymer-drug matrix by controlling the relevant parameters such as polymer molecular weight, ratio of lactide to glycolide and drug concentration to achieve a desired dosage and release interval depending upon the drug type ”
The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review. (2011, background): “…which factors that effect drug release from mainly poly(lactic acid) (PLA)-based DDSs (Alexis, 2005), the encapsulation and release of hydrophobic drugs (Wiscke and Schwendeman, 2008), and the encapsulation and release of macromolecular drugs in PLGA and its derivates (Mundargi et al., 2008).”
Biocompatibility of engineered nanoparticles for drug delivery. (2013, background): “These particles are known as clinically proven biodegradable and biocompatible materials [40].”