Abstract 1006: Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
By M. Hangauer, V. Viswanathan, M. Ryan, Dhruv Bole, J. Eaton, A. Matov, Jacqueline Galeas, Harshil Dhruv, M. Berens, Stefan Schreiber and 2 more. 2017
890 citations recorded by the source corpus.
Subfields: Computational Theory and Mathematics, Pharmacology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/5ada0316b2a93614ba85235547df641ac0f47548
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In Pharmacology
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress (2018, background): “…a mesenchymal or persister cell state is highly dependent on GPX4 peroxidase activity for survival, highlighting the potential for co-treatment with GPX4 inhibitors to overcome epithelial-mesenchymal transition (EMT)-related resistance mechanisms (Hangauer et al., 2017; Viswanathan et al., 2017).”
- The interaction between ferroptosis and lipid metabolism in cancer (2020, background): “Some chemotherapies are sensitive to ferroptosis induced by GPX4 inhibition.(83,84) Moreover, as a key regulator of lipid metabolism, ACSL4 also produces LPO during the process of ferroptosis.”
- Intratumor heterogeneity: the Rosetta stone of therapy resistance (2020, background): “Drug tolerance is often thought as a distinct, well-defined phenotypic state that might be defined by similar molecular underpinnings across multiple cancer types such as dependency on certain metabolic pathways (Hangauer et al., 2017).”
- Regulated cell death (RCD) in cancer: key pathways and targeted therapies (2022, background): “Tumor cells such as diffuse large B-cell lymphoma and renal cell carcinoma have been found to be very sensitive to ferroptosis regulated by GPX4,(43) and some drug-resistant tumor cells are also highly dependent on GPX4 to maintain their own survival.(374) Therefore, GPX4 is a new target for some tu”
- Role of Mitochondria in Ferroptosis (2018, background): “, 2016); and many types of cancer cells that are resistant to chemotherapy and certain targeted therapies appear to be sensitive to ferroptosis induced by GPX4 inhibition (Hangauer et al., 2017; Viswanathan et al., 2017).”