Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

By Dominik Paquet, Dylan G. Kwart, Antonia Chen, A. Sproul, Samson Jacob, Shaun Teo, Kimberly Moore Olsen, Andrew Gregg, S. Noggle, M. Tessier-Lavigne. Nature, 2016

856 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5ac7b91ea4b94a9c9f459313d45321eaad8dd6c5

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In Molecular Biology

1. Min Wu
2. Mengyuan Huang
3. Hongyi Li
4. Xia Zhao
5. Yang Yang
6. Jerilyn A. Timlin
7. J. Carney
8. J. C. Harper

Citations in the corpus

• Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects (2020, background): “In addition, through a gene editing platform based on single-stranded oligonucleotide DNA nucleotides and CRISPR/CAS-blocking mutations, Paquet et al.(131) generated human iPSCs with dominant ADcausing mutations in APP and presenilin 1 (PSEN1), both heterozygous and homozygous, leading to early dise”
• Delivering CRISPR: a review of the challenges and approaches (2018, background): “cells (Paquet et al., 2016), and correct mutations that cause DMD (Ousterout et al.”
• Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage (2017, neutral): “Comparison between ABE 7.10 and homology directed repair using the ‘CORRECT’ method 42 HEK293T cells grown in the absence of antibiotic were seeded on 48-well poly-D-lysine coated plates (Corning).”