ChAMP: updated methylation analysis pipeline for Illumina BeadChips

By T. Morris, A. Webster, Zhen Yang, Stephan Beck, A. Feber, Andrew E. Teschendorff. Bioinform., 2017

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Summary: The Illumina Infinium HumanMethylationEPIC BeadChip is the new platform for high‐throughput DNA methylation analysis, effectively doubling the coverage compared to the older 450 K array. Here we present a significantly updated and improved version of the Bioconductor package ChAMP, which can be used to analyze EPIC and 450k data. Many enhanced functionalities have been added, including correction for cell‐type heterogeneity, network analysis and a series of interactive graphical user interfaces. Availability and implementation: ChAMP is a BioC package available from https://bioconductor.org/packages/release/bioc/html/ChAMP.html. Contact: a.teschendorff@ucl.ac.uk or s.beck@ucl.ac.uk or a.feber@ucl.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5a86587aaecf74bc52fb1a11c2abc21f04b21cbe