Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition

By M. Chambers, J. Atack, H. Broughton, N. Collinson, Susan M. Cook, G. Dawson, S. C. Hobbs, G. Marshall, K. Maubach, G. Pillai and 2 more. 2003

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Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning (2015, background): “These findings illustrate the importance of tonic GABA effects on various parameters of SPW-Rs and may explain, at least partly, the memory decreasing and enhancing effects of etomidate and L-655,708, respectively (Chambers et al., 2003; Cheng et al., 2006; Atack et al., 2006; Martin et al., 2009).”
Synaptic and nonsynaptic localization of GABAA receptors containing the α5 subunit in the rat brain (2006, background): “Selective inverse agonists for 5-GABAARs enhance memory in animal models (Chambers et al., 2003; Maubach, 2003) and pharmaceutical companies are thought to be developing some of these Grant sponsor: National Institute of Neurological Disorders and Stroke (NINDS) (NIH); Grant number: NS39287.”