Enhanced bioactivity of ZnO nanoparticles—an antimicrobial study

By N. Padmavathy, R. Vijayaraghavan. Science and Technology of Advanced Materials, 2008

1,654 citations recorded by the source corpus.

Abstract In this study, we investigate the antibacterial activity of ZnO nanoparticles with various particle sizes. ZnO was prepared by the base hydrolysis of zinc acetate in a 2-propanol medium and also by a precipitation method using Zn(NO3)2 and NaOH. The products were characterized by x-ray diffraction (XRD) analysis, transmission electron microscopy (TEM) and photoluminescence (PL) spectroscopy. Bacteriological tests such as minimum inhibitory concentration (MIC) and disk diffusion were performed in Luria-Bertani and nutrient agar media on solid agar plates and in liquid broth systems using different concentrations of ZnO by a standard microbial method for the first time. Our bacteriological study showed the enhanced biocidal activity of ZnO nanoparticles compared with bulk ZnO in repeated experiments. This demonstrated that the bactericidal efficacy of ZnO nanoparticles increases with decreasing particle size. It is proposed that both the abrasiveness and the surface oxygen species of ZnO nanoparticles promote the biocidal properties of ZnO nanoparticles.

Subfields: Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/5a639940476d4d276aec719faa373ff6575e60e0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

Citations in the corpus

In Vitro Antibacterial Activity and Minimum Inhibitory Concentration of Zinc Oxide and Nano-particle Zinc oxide Against Pathogenic Strains (2012, background): “Nagarajan and Rajagopalan 2008 (15) reported that the activity was affected by particle size, which is controlled by processing parameters.”
Zinc Oxide—From Synthesis to Application: A Review (2014, background): “[215] showed that ZnO nanoparticles were more abrasive than bulk ZnO (particle sizes in the range 0.”
Biosynthesis of metallic nanoparticles using plant extracts and evaluation of their antibacterial properties (2018, background): “Therefore, the H2O2 molecules generated can penetrate into the cell membrane and kill the bacteria [60, 61].”
Chitosan/nano ZnO composite films: Enhanced mechanical, antimicrobial and dielectric properties (2018, result): “All these data were in well agreement with the data base of ZnO particles (JCPDS No. 1436-51) (Padmavathy and Vijayaraghavan, 2008; Prabhu and Rao, 2014; Sarma and Sarma, 2014).”
Biosynthesis of silver and zinc oxide nanoparticles using Pichia fermentans JA2 and their antimicrobial property (2014, background): “ZnO nanomaterials are also being considered for use in next-generation biological applications including antimicrobial agents, drug delivery and bioimaging probes (Padmavathy and Vijayaraghavan 2008).”
Zinc Oxide Nanoparticles: Synthesis, Antimicrobial Activity and Food Packaging Applications (2012, methodology): “Similar results have been reported by Padmavathy and Vijayaraghavan (2008), indicating that the ZnO nanoparticle suspensions in lower concentrations (0.01–1 mM) seem to have less antimicrobial activity against E. coli, and the presence of soluble Zn2+ ions may act as nutrients for this…”
Antimicrobial applications of nanotechnology: methods and literature (2012, background): “coli was observed at the 18-hour time point as the particle diameter was reduced from 2 μm to 45 nm to 12 nm, and this was attributed to the enhanced effect of the greater surface area to volume ratios and mechanical damage caused to the cells due to increased abrasiveness of the smaller nanoparticl”