Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders
By C. Beall, G. Cavalleri, Libin Deng, R. Elston, Yang Gao, J. Knight, Chaohua Li, Jiang Li, Yu Liang, M. McCormack and 19 more. Proceedings of the National Academy of Sciences of the United States of America, 2010
806 citations recorded by the source corpus.
Subfields: Cancer Research, Genetics, Physiology
View Paper: https://www.semanticscholar.org/paper/5a33cb176cb4c982b5e0fde3ff2c843767599664
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In Genetics
- Torsten Günther
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- M. Jobling
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- Oscar E. Gaggiotti
Citations in the corpus
- Robust Identification of Local Adaptation from Allele Frequencies (2012, background): “Outlook The population genomic comparison of closely related populations that differ strongly in environmental variables has already yielded many great candidate loci (see for example, altitude adaptation in Tibetans, Beall et al., 2010; Simonson et al., 2010; Yi et al., 2010).”
- Genetic adaptation to high altitude in the Ethiopian highlands (2012, background): “Three genes have been previously implicated in highaltitude adaptation in Tibetan populations (EPAS1, EGLN1, and PPARA) [9,11,12].”
- Demographic History and Genetic Adaptation in the Himalayan Region Inferred from Genome-Wide SNP Genotypes of 49 Populations (2018, background): “2015), and rs982414, an intronic variant 231 kb downstream of EPAS1, which has been associated with hemoglobin concentration in Tibetans (Beall et al. 2010).”