Occurrence of antibiotics and antibiotic resistance genes in a sewage treatment plant and its effluent-receiving river.

By Jian Xu, Yan Xu, Hongmei Wang, Changsheng Guo, Huiyun Qiu, Yan He, Y. Zhang, Xiaochen Li, W. Meng. Chemosphere, 2015

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Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements. (2017, background): “Other studies have also 340 M AN US CR IP T AC CE PT ED 15 indicated that WWTPs might be a hotspot for the occurrence of ARGs (Zhang and Li, 2011; Yang et 341 al., 2014a; Xu et al., 2015).”
Review of antibiotic resistance in China and its environment. (2018, neutral): “…total 16S rRNA gene copy number), higher total loads of ARGs was observed in pharmaceutical STPs (10 − 4 – 10 0 copies/ copy 16SrRNA gene) than in municipal STPs (10 − 9 – 10 − 1 copies/copy 16SrRNA gene) (Huang et al., 2015a; Li et al., 2016a; Liu et al., 2012; Xu et al., 2015; Zhai et al., 2016).”