Cooperation of Liver Cells in Health and Disease

By Z. Kmieć. Advances in Anatomy, Embryology and Cell Biology, 2001

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GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies (2004, neutral): “production of acute phase proteins [23]).”
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “…cells and their role in hepatotoxicity The major cell type of the liver is the hepatocyte, a parenchymal cell, which makes up to 80 % of the entire liver mass and performs the majority of the liver functions (Kmiec 2001; Lippincott 1993; Saunders 1996; Michalopoulos 2007; Tanaka et al. 2011).”
The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. (2006, background): “A loss of membrane integrity not only leads to the release of cellular contents, but also increases theinﬂuxofextracellular componentsincludingcytokines(Curry, 1992; Kmiec, 2001).”
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets (2006, background): “They synthesize a broad spectrum of cytokines and growth factor-binding proteins including epidermal growth factor, insulin-like growth factor-I and –II, insulin-like-growth factor binding proteins, interleukins, macrophage colonystimulating factor, latent TGF-β-binding proteins, CTGF, chemokines, a”