The strategy of the genes : a discussion of some aspects of theoretical biology

By C. Waddington. 2014

1,111 citations recorded by the source corpus.

Subfields: Astronomy and Astrophysics, History and Philosophy of Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/594e1234951ecb9ec27d9f285c223f91c3ab2a63

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Citations in the corpus

Single-cell RNA sequencing technologies and bioinformatics pipelines (2018, background): “As Kacser and Waddington 59 noted in his metaphor for cellular plasticity, cells possess an enormous “ landscape ” of potential states that they can adopt over the course of development and in disease progression.”
DNA methylation: a historical perspective. (2022, neutral): “As an aside, it is worth mentioning that in parallel to these experimental advances, the developmental biologist Conrad Waddington coined the term ‘epigenetics’ in 1942 [36] and published his widely used epigenetic landscape in 1957 [37]; however, these concepts were not linked to DNA methylation un”
Drivers of human development: How relationships and context shape learning and development1 (2020, background): “The epigenetic landscape (Waddington, 1956, 1957), which includes more than cellular epigenetic inheritance processes, can be expanded (Griffiths & Hochman, 2015).”
Control Principles of Complex Networks (2015, background): “The obtained ESN captures the global architecture of stable cell phenotypes, helping us translate the metaphorical Waddington epigenetic landscape concept (Slack, 2002; Waddington and Kacser, 1957) into a mathematical framework of cell phenotypic transitions.”
Mapping Transcriptomic Vector Fields of Single Cells (2022, background): “Publi This is an open access article under the CC BY license (http://creative epigenetic landscape, a metaphor in which differentiation proceeds similar to a ball sliding downhill into various valleys (Waddington, 1957).”
Everything Flows : Towards a Processual Philosophy of Biology (2018, background): “‘The fundamental characteristics of the organism’, he wrote in The Strategy of the Genes, ‘are time-extended properties’ (Waddington 1957: 189).”
Reprogramming to recover youthful epigenetic information and restore vision (2020, positive): “The metaphor of the epigenetic landscape, first invoked by Waddington to explain embryonic development 8 , is increasingly seen as relevant to the other end of life 9 .”
Pathways to Integrated Resilience Science (2015, methodology): “These models were influenced by earlier pathway models for development proposed by Waddington (1957), Sroufe and others (e.g., Sroufe et al., 2005), as well as models of pathways toward or away from mental illness depicted by Gottesman and colleagues (Gottesman, 1974; Gottesman & Shields, 1982).”
Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming (2019, neutral): “…uthor M anuscript A uthor M anuscript Introduction Waddington introduced two metaphors that shaped biological thinking about cellular differentiation: first, trains moving along branching railroad tracks and, later, marbles rolling through a developmental landscape (Waddington, 1936, 1957).”
A Manifesto for a Processual Philosophy of Biology (2018, background): ““The fundamental characteristics of the organism”, he wrote in The Strategy of the Genes, “are time-extended properties” (Waddington 1957: 189).”