RNA modifications modulate gene expression during development

By Michaela Frye, Bryan T. Harada, Mikaela Behm, Chuan He. Science, 2018

1,014 citations recorded by the source corpus.

RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA (mRNA) modifications regulate various aspects of mRNA metabolism. For example, N6-methyladenosine (m6A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition. Similarly, some modifications in transfer RNAs are essential for RNA structure and function. Others are deposited in response to external cues and adapt global protein synthesis and gene-specific translational accordingly and thereby facilitate proper development.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/58b2380ff672c9f957fdbf55bd85c0fae470a845

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Hailing Shi
2. Chuan He

In Molecular Biology

1. Hailing Shi
2. Jiangbo W
3. Chuan He
4. Samie R. Jaffrey
5. P. He
6. S. Zaccara

Citations in the corpus

• Where, when and how: context-dependent functions of RNA methylation writers, readers, and erasers (2019, background): “, 2017a), animal development (Frye et al., 2018), and human diseases (Hsu et al.”
• Functions of N6-methyladenosine and its role in cancer (2019, background): “Epigenetics has become a hot topic in scientific research nowadays [37, 163].”
• Targeting FTO suppresses cancer stem cell maintenance and immune evasion (2020, neutral): “Among the >170 modified RNA nucleotides, N6-methyladenosine (m6A) represents the most abundant and prevalent internal modification in eukaryotic mRNA (Boccaletto et al., 2018; Frye et al., 2018).”
• Methylation multiplicity and its clinical values in cancer (2021, neutral): “9); protein methylation affects protein activities and directs protein translation, localisation and signalling (Ref.”