Cancer cell motility: lessons from migration in confined spaces
By C. Paul, P. Mistriotis, K. Konstantopoulos. Nature Reviews. Cancer, 2016
595 citations recorded by the source corpus.
Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through confining microenvironments are not predicted by 2D migration assays. Engineered in vitro models have been used to delineate the mechanisms of cell motility through confining spaces encountered in vivo. Understanding cancer cell locomotion through physiologically relevant confining tracks could be useful in developing therapeutic strategies to combat metastasis.
Subfields: Biomedical Engineering, Cell Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/58aad6d933382b63219d6bc1bb66d10b2b0053cf
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In Biomedical Engineering
In Cell Biology
In Oncology
Citations in the corpus
- Physical traits of cancer (2020, background): “The architecture of the local environment can also drastically affectmigration (136).”