Inflammatory microenvironment remodelling by tumour cells after radiotherapy

By M. McLaughlin, E. Patin, M. Pedersen, A. Wilkins, M. Dillon, A. Melcher, Kevin J. Harrington. Nature Reviews. Cancer, 2020

746 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/58a876ffbaf13b412f7431bbcfba505356eda606

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Yan Yu
2. Weitong Gao
3. Yang Zhou
4. Xuepeng Wang

Citations in the corpus

• Neoantigens: promising targets for cancer therapy (2023, background): “Peptides derived from mutant KPNA2 trigger neoantigen-reactive CD8 T cells and induce IFNγ production, which may trigger antigen spread.(472,473) In addition, radiation can enhance the levels of existing peptide presentation by increasing the surface expression of MHC-I on tumor cells.”
• Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “However, it was found that in some solid tumors, DNA fragments generated by ionizing radiation can be recognized by intracellular DNA sensors such as AIM2 or ZBP1 thereby activating inflammatory signaling and inducing pyroptosis.(441,442) Cytosolic DNA can also activate another DNA sensor, the STING”