Neural circuits for long-term water-reward memory processing in thirsty Drosophila

By Wei-Huan Shyu, Tai-Hsiang Chiu, Meng-Hsuan Chiang, Yuanyuan Cheng, Ya-Lun Tsai, Tsai-Feng Fu, Tony Wu, Chia-Lin Wu. 2017

46 citations recorded by the source corpus.

The intake of water is important for the survival of all animals and drinking water can be used as a reward in thirsty animals. Here we found that thirsty Drosophila melanogaster can associate drinking water with an odour to form a protein-synthesis-dependent water-reward long-term memory (LTM). Furthermore, we found that the reinforcement of LTM requires water-responsive dopaminergic neurons projecting to the restricted region of mushroom body (MB) β′ lobe, which are different from the neurons required for the reinforcement of learning and short-term memory (STM). Synaptic output from α′β′ neurons is required for consolidation, whereas the output from γ and αβ neurons is required for the retrieval of LTM. Finally, two types of MB efferent neurons retrieve LTM from γ and αβ neurons by releasing glutamate and acetylcholine, respectively. Our results therefore cast light on the cellular and molecular mechanisms responsible for processing water-reward LTM in Drosophila. Distinct subsets of dopaminergic PAM neurons have been shown to be involved in short-term and long-term memory for sugar reward. Here the authors report the neural circuits and the cellular and molecular mechanisms for short-term and long-term memory for water reward in thirstyDrosophila.

Subfields: Cellular and Molecular Neuroscience, Ecology, Genetics

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In Cellular and Molecular Neuroscience

1. Qian Li
2. Liyuan Wang
3. Xuchen Zhang
4. Yi Zhong
5. Wantong Hu
6. Bohan Zhao
7. Jianjian Zhao

In Ecology

1. Liyuan Wang

In Genetics

1. Liyuan Wang
2. Yi Zhong
3. Qian Li
4. Xuchen Zhang

Citations in the corpus

• Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila (2022, positive): “5-HT1B-Gal4 (Gao et al., 2019; Shyu et al., 2017; Yuan, Lin, Zheng, & Sehgal, 2005), VT30604-Gal4 (Wu, Shih, Lee, & Chiang, 2013), and C739-Gal4 (O’Dell, Armstrong, Yang, & Kaiser, 1995) were used to drive transgene expression in γ neurons, α’/β’ neurons, and α/β neurons.”
• Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila (2019, unknown): “, 2012), water (Lin et al., 2014; Shyu et al., 2017) and alcohol reward (Scaplen et al.”
• Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting. (2018, unknown): “To manipulate Raf in g neurons, we combined specific Gal4 lines (5-HT1B for g neurons andC739 for a/b neurons) used previously (O’Dell et al., 1995; Shyu et al., 2017; Xie et al., 2013; Yuan et al., 2005) with another inducible expression system called TARGET, which relies on a temperature shift to…”