A general amphipathic α-helical motif for sensing membrane curvature

By Guillaume Drin, J. Casella, Romain Gautier, Thomas Boehmer, T. Schwartz, Bruno Antonny. Nature Structural &Molecular Biology, 2007

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Membrane curvature at a glance (2015, background): “Active membrane pulling or pushing by kinesins, dynein and myosin also induces considerable membrane reorganization and supports some of the organelle morphologies (e.g. ER, Golgi and endosomes) (reviewed in Leduc et al., 2010).”
The synapsins: key actors of synapse function and plasticity. (2010, background): “This would enable proteins to selectively target these organelles, purely on the basis of their geometry (Drin et al., 2007).”
HELIQUEST: a web server to screen sequences with specific alpha-helical properties (2008, background): “Introducing two basic residues in the polar face was enough to create a curvatureinsensitive helix interacting with flat membranes (Drin et al. 2007).”