Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

By V. Hernández-Gea, S. Toffanin, S. Friedman, J. Llovet. Gastroenterology, 2013

698 citations recorded by the source corpus.

Hepatocellular carcinoma (HCC) is the most common primary liver tumor and the third cause of cancer-related death worldwide, and its incidence is increasing. Despite the significant improvement in HCC management in the last 30 years, there are no effective chemoprevention strategies, and only 1 systemic therapy has been approved for patients with advanced tumors. This drug, sorafenib, acts on tumor cells and the stroma. HCC develops from chronically damaged tissue that contains large amounts of inflammation and fibrosis, which also promote tumor progression and resistance to therapy. Increasing our understanding of how stromal components interact with cancer cells and the signaling pathways involved could identify new therapeutic and chemopreventive targets.

Subfields: Cancer Research, Hepatology

View Paper: https://www.semanticscholar.org/paper/5845331f69a8bf43832ee5fe58848ea4019948a0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Robert F. Schwabe
2. Le-xing Yu
3. S. Affò

In Hepatology

1. J. Rowe
2. Robert F. Schwabe
3. Idrees Mian
4. Le-xing Yu
5. S. Affò
6. Yezaz A. Ghouri

Citations in the corpus

• Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis (2017, background): “[79] HIF‐1α is stimulated by hypoxic conditions and play a synergistic role with other angiogenic factors, especially VEGF in counteracting apoptosis and promoting cell proliferation.[77,78] In addition, hypoxia induces autophagy which generates energy for tumor cells and its surrounding environment”
• The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer (2016, background): “Moreover, MMPs are required to promote tumor spread within the often highly fibrotic livers in which HCCs arise as they help break down tumor boundaries and promote tumor cell invasion (19).”