The Human Microbiome: Our Second Genome

By Elizabeth A. Grice, J. Segre. Annual review of genomics and human genetics (Print), 2012

626 citations recorded by the source corpus.

The human genome has been referred to as the blueprint of human biology. In this review we consider an essential but largely ignored overlay to that blueprint, the human microbiome, which is composed of those microbes that live in and on our bodies. The human microbiome is a source of genetic diversity, a modifier of disease, an essential component of immunity, and a functional entity that influences metabolism and modulates drug interactions. Characterization and analysis of the human microbiome have been greatly catalyzed by advances in genomic technologies. We discuss how these technologies have shaped this emerging field of study and advanced our understanding of the human microbiome. We also identify future challenges, many of which are common to human genetic studies, and predict that in the future, analyzing genetic variation and risk of human disease will sometimes necessitate the integration of human and microbial genomic data sets.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5833bd271155555f5ac6711c892b55e4379f1f03

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In Molecular Biology

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Citations in the corpus

• Microbiota in health and diseases (2022, background): “In addition, the human microbiota, also known as “the hidden organ,” contribute over 150 times more genetic information than that of the entire human genome.(2) Although “microbiota” and “microbiome” are often interchangeable, there are certain differences between the two terms.”
• Advances and Trends in Omics Technology Development (2022, background): “…models of microbiome studies has suggested strong associations between microbiomes and human diseases (256), and microbiome can provide unique insights into human diseases, with unprecedented ability demonstrated in interrogating and modulating the communities that co-inhabit with human (257, 258).”
• Engineering Modular Viral Scaffolds for Targeted Bacterial Population Editing (2015, positive): “Furthermore, despite the important role that microbial populations play in regulating human health and disease (Grice and Segre, 2012), strategies for precisely manipulating complex mi-”