LC-MS Data Processing with MAVEN: A Metabolomic Analysis and Visualization Engine

By Michelle F. Clasquin, Eugene Melamud, Joshua D. Rabinowitz. Current Protocols in Bioinformatics, 2012

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MAVEN is an open-source software program for interactive processing of LC-MS-based metabolomics data. MAVEN enables rapid and reliable metabolite quantitation from multiple reaction monitoring data or high-resolution full-scan mass spectrometry data. It automatically detects and reports peak intensities for isotope-labeled metabolites. Menu-driven, click-based navigation allows visualization of raw and analyzed data. Here we provide a User Guide for MAVEN. Step-by-step instructions are provided for data import, peak alignment across samples, identification of metabolites that differ strongly between biological conditions, quantitation and visualization of isotope-labeling patterns, and export of tables of metabolite-specific peak intensities. Together, these instructions describe a workflow that allows efficient processing of raw LC-MS data into a form ready for biological analysis.

Subfields: Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/58249091b81a9d642abd30a716e0b5918c0be6a8

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