Models of the Aging Brain Structure and Individual Decline

By Gabriel Ziegler, Robert Dahnke, Christian Gaser. Front. Neuroinform., 2012

510 citations recorded by the source corpus.

The aging brain’s structural development constitutes a spatiotemporal process that is accessible by MR-based computational morphometry. Here we introduce basic concepts and analytical approaches to quantify age-related differences and changes in neuroanatomical images of the human brain. The presented models first address the estimation of age trajectories, then we consider inter-individual variations of structural decline, using a repeated measures design. We concentrate our overview on preprocessed neuroanatomical images of the human brain to facilitate practical applications to diverse voxel- and surface-based structural markers. Together these methods afford analysis of aging brain structure in relation to behavioral, health, or cognitive parameters.

Subfields: Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/5820d63569ded5a2493d8497f487d7f2d6698ff9

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In Cognitive Neuroscience

  1. Olivier Colliot

In Radiology, Nuclear Medicine and Imaging

  1. Jorge Samper-González
  2. Elina Thibeau-Sutre
  3. Junhao Wen
  4. Alexandre Routier
  5. Olivier Colliot
  6. Stanley Durrleman
  7. Ninon Burgos
  8. Simona Bottani

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