The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?
By Timothy J. Ritchie, Simon J. F. Macdonald. Drug Discovery Today, 2009
762 citations recorded by the source corpus.
Subfields: Computational Theory and Mathematics, Immunology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/57d8b0f87cc9ae2b040ee31e2ac4be24d537e315
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In Computational Theory and Mathematics
In Immunology
In Pharmacology
Citations in the corpus
- Lipophilicity in drug discovery (2010, background): “Along these lines, it has been suggested that reduction of molecular weight [21,35,40], removal of aromatic rings [75] and increased saturation or added chirality [76] might offer generic means of achieving this.”
- The Structure and Function of DNA G-Quadruplexes (2020, background): “optimal for a small molecule with good pharmacokinetic properties [34,35].”
- Quantifying the chemical beauty of drugs. (2012, background): “, number of hydrogen bond donors (HBDs), number of hydrogen bond acceptors (HBAs), molecular polar surface area (PSA), number of rotatable bonds (ROTBs), number of aromatic rings (AROMs”
- Molecular obesity, potency and other addictions in drug discovery (2011, background): “While clearly related in a non-linear manner to lipophilicity, the analysis of this property by Ritchie and MacDonald gives interesting insights which can be summarized as “the fewer aromatic rings in an oral drug candidate the better” with less than three being suggested as an appropriate target nu”