Mechanisms of hepatic stellate cell activation

By Takuma Tsuchida, S. Friedman. Nature Reviews Gastroenterology &Hepatology, 2017

2,595 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives (2020, background): “, ROS) will be further discussed in this section [57,60].”
Cholangiocarcinoma 2020: the next horizon in mechanisms and management (2020, positive): “In CCA, the persistent activation of fibroblasts is induced primarily by TGFβ, fibroblast growth factor and PDGF, which are released from tumour-associated macrophages and CCA cells 204 .”
TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019 (2019, background): “ROS plays crucial roles in liver fibrosis and HSC activation [9,145].”
Mechanisms and disease consequences of nonalcoholic fatty liver disease (2021, background): “This peri-sinusoidal resident cell type undergoes a specialized trans-differentiation or ‘‘activation,’’ which comprises a transition from a quiescent vitamin A-rich cell to one that is fibrogenic, proliferative, and proinflammatory (Tsuchida and Friedman, 2017).”
Targeting TGF-β signal transduction for fibrosis and cancer therapy (2022, background): “Hepatic stellate cells (HSCs) are turned into hepatocellular carcinoma (HCC) cells [70, 71].”
Hepatic inflammatory responses in liver fibrosis (2023, neutral): “162 .”