How many drug targets are there?

By John P. Overington, B. Al-Lazikani, A. Hopkins. 2006

3,528 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Organic Chemistry, Radiology, Nuclear Medicine and Imaging

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Citations in the corpus

3D structures of membrane proteins from genomic sequencing (2012, neutral): “More than 25% of all human proteins have integral membrane domains; many of these are medically important, with nearly half of all drug targets containing a membrane domain (Bakheet and Doig, 2009; Overington et al., 2006).”
Structure of the human histamine H1 receptor complex with doxepin (2011, neutral): “Many of these compounds inhibit the action of histamine on H 1 R to alleviate the symptoms of allergic reactions, making H 1 R one of the most validated drug targets judging from the number of drugs approve”
GPCR-ModSim: A comprehensive web based solution for modeling G-protein coupled receptors (2016, background): “It is estimated that between 30 and 40% of marketed drugs target a GPCR (2), including many blockbusters in the pharmaceutical industry.”
Protein Structure Prediction and Design in a Biologically Realistic Implicit Membrane. (2020, background): “M 1⁄4 sinðqðzÞÞ cosðqðzÞÞ cosðqðzÞÞ sinðqðzÞÞ ; (2)”
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond (2016, neutral): “G protein-coupled receptors (GPCRs) represent the largest human drug target class [9]; they affect neurological and cardiovascular physiology and are included in routine safety pharmacology panels [10].”
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery (2011, background): “drug approval, clinical trial or investigations) of the corresponding drugs as confirmed by biochemical assay and strong cell based and/or in vivo evidence linking the target to drug (15,17,22).”
Generic GPCR Residue Numbers - Aligning Topology Maps Minding The Gaps (2014, background): “Their abundance in human physiological systems, as well as their accessibility and druggability, have made them a major drug target family – (cid:2) 30% of the marketed drugs act on GPCRs [3].”