Sex Modifies the APOE-Related Risk of Developing Alzheimer's Disease

By André Altmann, Lu Tian, Victor W. Henderson, Michael D. Greicius. Annals of Neurology, 2014

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The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer disease (AD). Case–control studies suggest the APOE4 link to AD is stronger in women. We examined the APOE4‐by‐sex interaction in conversion risk (from healthy aging to mild cognitive impairment (MCI)/AD or from MCI to AD) and cerebrospinal fluid (CSF) biomarker levels.

Subfields: Cardiology and Cardiovascular Medicine, Physiology, Psychiatry and Mental health

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