Phage treatment of human infections

By S. Abedon, Sarah J Kuhl, B. Blasdel, E. Kutter. Bacteriophage, 2011

920 citations recorded by the source corpus.

Phages as bactericidal agents have been employed for 90 years as a means of treating bacterial infections in humans as well as other species, a process known as phage therapy. In this review we explore both the early historical and more modern use of phages to treat human infections. We discuss in particular the little-reviewed French early work, along with the Polish, US, Georgian and Russian historical experiences. We also cover other, more modern examples of phage therapy of humans as differentiated in terms of disease. In addition, we provide discussions of phage safety, other aspects of phage therapy pharmacology, and the idea of phage use as probiotics.

Subfields: Ecology, Microbiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/5798525942bbb92848447da3486e3a3bcc594ea6

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Citations in the corpus

Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review (2019, methodology): “Readers may refer to previous reviews published on phage therapy which have described in numerous studies (Abedon et al., 2011; Chan et al., 2013; Górski et al., 2017; Lin et al., 2017; Sybesma et al., 2018).”
Advantages and Limitations of Bacteriophages for the Treatment of Bacterial Infections (2019, background): “However, mainly because most antibiotics were not available, BPs continued to be used in Russia and in Eastern Europe, particularly in those countries previously included in the Soviet Union (Abedon et al., 2011).”
The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “Humans: In addition to controlled animal and plant studies of phage therapy, there is a large body of the postWorld War II clinical literature on phage therapy of humans that has been carried out primarily in Poland (reviewed by Abedon et al. 2011).”
Phage cocktails and the future of phage therapy. (2013, background): “A number of recent reviews have investigated the question of phage therapy efficacy explicitly in humans [8–10,14].”
VICTOR: genome-based phylogeny and classification of prokaryotic viruses (2017, background): “In recent years, the interest in bacteriophages as therapeutic agents to fight serious bacterial infections caused by multi-resistant strains (Abedon et al. 2011) experienced a renaissance (Thacker 2003).”