A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

By D. Rubinson, C. Dillon, A. Kwiatkowski, C. Sievers, Lili Yang, J. Kopinja, Dina L Rooney, Mingdi Zhang, M. Ihrig, Michael T. McManus and 3 more. Nature Genetics, 2003

1,619 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5766384c2b12f46e191eb5c2b69e78aa9eab52b0

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In Genetics

1. R. Abraham
2. S. Morrison

In Molecular Biology

1. R. Abraham
2. S. Morrison

Citations in the corpus

• Jurkat T cells and development of the T-cell receptor signalling paradigm (2004, background): “Nonetheless, many laboratories are now applying siRNAs to various lymphoid cell lines, and it is most encouraging to learn that siRNA technology can be used to silence genes in normal human T cell”
• Hmga2 promotes neural stem cell self-renewal in young, but not old, mice by reducing p16Ink4a and p19Arf expression (2008, methodology): “To test whether elevated expression of let-7b in neural stem cells could reduce their self-renewal potential, we overexpressed let-7b and GFP in wild-type cells cultured from P0 VZ using a dual promoter lentivirus (Rubinson et al., 2003).”