Acute toxicity of ammonia and its sub‐lethal effects on selected haematological and enzymatic parameters of mrigal, Cirrhinus mrigala (Hamilton)
By P. Das, S. Ayyappan, J. Jena, B. Das. 2004
160 citations recorded by the source corpus.
A comprehensive acute toxicity trial was conducted using a static water system to study the toxic effect of ammonia on haematology and enzyme profiles of Cirrhinus mrigala H. The LC50 of total ammonia-nitrogen (TAN) was 11.8 mg L−1 TAN (1.029 mg L−1 NH3-N). The sub-lethal test revealed that with increasing concentration of TAN, the total erythrocyte counts were reduced in lower concentrations (1–4 mg L−1 TAN) followed by higher levels in fish exposed to higher concentrations (8–16 mg L−1 TAN). In contrast, the total leucocyte counts were opposite. With increasing concentration of TAN, haemoglobin and serum protein content were reduced, whereas the blood glucose level increased. As the concentration of ammonia increased, there was a reduction in acetylecholinesterase activity in the brain and liver; alkaline phosphatase activity in the serum, brain and gill; and acid phosphatase (ACP) activity in the gill. The activity of lactate dehydrogenase in the gill, liver, kidney and brain increased with increased concentration of ammonia. In addition, activities of ACP in the serum and brain, alanine aminotransferase in the serum, brain and gill, and aspartate aminotransferase in the serum, brain and gill were increased.
Subfields: Aquatic Science, Health, Toxicology and Mutagenesis, Immunology
View Paper: https://www.semanticscholar.org/paper/57474687e06e07d9c0ad5ad723680d2e3719fa33
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In Health, Toxicology and Mutagenesis
Citations in the corpus
- Responses of metabolic and antioxidant enzymatic activities in gill, liver and plasma of Catla catla during methyl parathion exposure (2016, background): “Prevalence of anoxia during stress conditions may lead to an increase in LDH activity in tissues (Das et al., 2004).”
- Enzymatic and histopathologic biomarkers as indicators of aquatic pollution in fishes (2010, background): “The cytoplasmic enzyme lactate dehydrogenase (LDH) is widely used as marker of organ or tissue lesions in toxicology and in clinical chemistry [32-34].”
- Performance of Nile Tilapia (Oreochromis niloticus) Fingerlings. I. Effect of pH (2009, background): “The average Hb concentration in the experimental groups at pH 7, 8 and 9 was not different from control (Pratap et al., 2004).”