Freezing of gait: moving forward on a mysterious clinical phenomenon

By J. Nutt, B. Bloem, Nir Giladi, Mark Hallett, A. Nieuwboer. Lancet Neurology, 2011

1,225 citations recorded by the source corpus.

Freezing of gait (FoG) is a unique and disabling clinical phenomenon characterised by brief episodes of inability to step or by extremely short steps that typically occur on initiating gait or on turning while walking. Patients with FoG, which is a feature of parkinsonian syndromes, show variability in gait metrics between FoG episodes and a substantial reduction in step length with frequent trembling of the legs during FoG episodes. Physiological, functional imaging, and clinical–pathological studies point to disturbances in frontal cortical regions, the basal ganglia, and the midbrain locomotor region as the probable origins of FoG. Medications, deep brain stimulation, and rehabilitation techniques can alleviate symptoms of FoG in some patients, but these treatments lack efficacy in patients with advanced FoG. A better understanding of the phenomenon is needed to aid the development of effective therapeutic strategies.

Subfields: Neurology

View Paper: https://www.semanticscholar.org/paper/574424d00b1f9df79fcca7b746dba080dd8dc402

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Citations in the corpus

• Large-scale frontoparietal theta, alpha, and beta phase synchronization: A set of EEG differential characteristics for freezing of gait in Parkinson’s disease? (2022, result): “This view is also consistent with previous studies that reported the association of visuospatial processing deficits and attention of the patient with FOG during walking (Nutt et al., 2011; Nantel et al., 2012; Silveira et al., 2015).”