The multifaceted role of CD4+ T cells in the regulation of CD8+ T cell memory maturation
By B. Laidlaw, Joe Craft, S. Kaech. Nature reviews. Immunology, 2015
650 citations recorded by the source corpus.
Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte populations show an increase in number and function after antigen encounter and more rapidly re-expand upon subsequent antigen exposure. Studies of immune memory have primarily focused on effector B cells and T cells with microbial specificity, using prime–challenge models of infection. However, recent work has also identified persistently expanded populations of antigen-specific regulatory T cells that protect against aberrant immune responses. In this Review, we consider the parallels between memory effector T cells and memory regulatory T cells, along with the functional implications of regulatory memory in autoimmunity, antimicrobial host defence and maternal–fetal tolerance. In addition, we discuss emerging evidence for regulatory T cell memory in humans and key unanswered questions in this rapidly evolving field.
Subfields: Biomaterials, Polymers and Plastics
View Paper: https://www.semanticscholar.org/paper/570e234588e8e8fc5b9b6b117f7924d15a82b1d2
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Citations in the corpus
- Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms (2020, background): “CD4 T cells also indirectly provide help for the anti-tumour CD8 CTL response by supporting and maintaining pro-inflammatory cross-presenting dendritic cells (DCs) [101], which in turn provide the three activating signals for CD8 CTLs [115, 117].”