Detection of biomarkers by MRS requires error analysis
By J. Hoch, M. Maciejewski, M. Gryk. 2008
437 citations recorded by the source corpus.
Manganas et al. (Reports, 9 November 2007, p. 980) used nuclear magnetic resonance spectroscopy to identify a biomarker of neural progenitor cells. However, their analysis relies on spectral processing methods that are known to be problematic. Absent detection using alternate methods of spectrum analysis or controls to quantify the false discovery rate, their conclusions may be premature.
Subfields: Radiology, Nuclear Medicine and Imaging, Spectroscopy
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Citations in the corpus
- Human Hippocampal Neurogenesis Persists throughout Aging (2018, neutral): “Efforts to evaluate AHN in vivo face limitations due to inadequate spatial resolution and the inability to accurately differentiate hippocampal sub-regions (Ho et al., 2013; Manganas et al., 2007; Ramm et al., 2009).”
- Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “One study using magnetic resonance imaging appears to be able to identify neural precursors in rodent and human hippocampus through a complex signal-processing method (Manganas et al., 2007), but this approach awaits independent confirmation.”
- RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus (2010, background): “…NSC frequency (Walker et al., 2008), histological studies in primates (Aizawa et al., 2010), and magnetic resonance spectroscopy studies in humans (Manganas et al., 2007) indicated that the stem cell pool in the aged dentate gyrus is reduced and that incomplete stem cell maintenance may play a…”
- Neurodegenerative disease and adult neurogenesis (2011, background): “Progress in spatially resolved spectroscopy in vivo is still limited, as the signals reported for NSCs in magnetic resonance spectroscropy (e.g. lipid signal at 1.28 ppm) (Manganas et al., 2007) are not yet specific for reflecting NSCs, but may also indicate cell death (Ramm et al., 2009).”
- Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years (2010, background): “a study using MR spectroscopy to assess adult neurogenesis in the adult human brain [69].”
- Mechanisms and functional implications of adult neurogenesis. (2008, positive): “In addition, a magnetic resonance spectroscopy-based strategy has been developed to monitor the number of neural progenitors in live animals and humans, confirming the presence of cell proliferation in the hippocampus and its absence in the cortex (Manganas et al., 2007).”
- The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “Technical advances in non-invasive in vivo imaging of neurogenesis using magnetic resonance imaging (MRI) or positron emission tomography (PET) may allow investigators to obtain quantitative data relating adult hippocampal neurogenesis to cognitive metrics in humans [91, 92].”
- Environmental enrichment and neurogenesis: from mice to humans (2015, methodology): “[54]”
- Structural Plasticity and Hippocampal Function (2010, background): “F or p er so na l u se o nl y. ANRV398-PS61-05 ARI 17 November 2009 19:45 Neural stem cells: cells that self-renew and are multipotent, giving rise to neurons and glia SGZ: subgranular zone Progenitor cells: proliferative progeny of stem cells that generate differentiated cells but that have a…”