Telomeres shorten at equivalent rates in somatic tissues of adults
By L. Daniali, A. Benetos, E. Susser, J. Kark, C. Labat, M. Kimura, Kunj K. Desai, M. Granick, A. Aviv. Nature Communications, 2013
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Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human studies of telomere attrition were predominantly conducted on leukocytes. However, findings in leukocytes cannot be generalized to other tissues. Here we measure telomere length in leukocytes, skeletal muscle, skin and subcutaneous fat of 87 adults (aged 19–77 years). Telomeres are longest in muscle and shortest in leukocytes, yet are strongly correlated between tissues. Notably, the rates of telomere shortening are similar in the four tissues. We infer from these findings that differences in telomere length between proliferative (blood and skin) and minimally proliferative tissues (muscle and fat) are established during early life, and that in adulthood, stem cells of the four tissues replicate at a similar rate. Telomere shortening as a result of cell proliferation has been implicated in human ageing. Here, Daniali and colleagues show that telomere length and the rate of age-dependent shortening vary between adults but are similar within tissues of the same individual.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/56f8bcb8f252d7517d72838f2bd6e550e20edbae
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Citations in the corpus
- A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking (2021, methodology): “Where appropriate, we converted DNAmTL and PCDNAmTL into units of years by assuming that telomere length shortens by 25 base pairs per year 65 .”