The Clinical and Chest CT Features Associated With Severe and Critical COVID-19 Pneumonia
By Kunhua Li, Jiong Wu, Faqi Wu, D. Guo, Linli Chen, Z. Fang, Chuanming Li. Investigative Radiology, 2020
1,104 citations recorded by the source corpus.
Objective The aim of this study was to investigate the clinical and computed tomography (CT) features associated with severe and critical coronavirus disease 2019 (COVID-19) pneumonia. Materials and Methods Eighty-three patients with COVID-19 pneumonia including 25 severe/critical cases and 58 ordinary cases were enrolled. The chest CT images and clinical data of them were reviewed and compared. The risk factors associated with disease severity were analyzed. Results Compared with the ordinary patients, the severe/critical patients had older ages, higher incidence of comorbidities, cough, expectoration, chest pain, and dyspnea. The incidences of consolidation, linear opacities, crazy-paving pattern, and bronchial wall thickening in severe/critical patients were significantly higher than those of the ordinary patients. Besides, severe/critical patients showed higher incidences of lymph node enlargement, pericardial effusion, and pleural effusion than the ordinary patients. The CT scores of severe/critical patients were significantly higher than those of the ordinary patients (P < 0.001). Receiver operating characteristic curve showed that the sensitivity and specificity of CT score were 80.0% and 82.8%, respectively, for the discrimination of the 2 types. The clinical factors of age older than 50 years, comorbidities, dyspnea, chest pain, cough, expectoration, decreased lymphocytes, and increased inflammation indicators were risk factors for severe/critical COVID-19 pneumonia. Computed tomography findings of consolidation, linear opacities, crazy-paving pattern, bronchial wall thickening, high CT scores, and extrapulmonary lesions were features of severe/critical COVID-19 pneumonia. Conclusions There are significant differences in clinical symptoms, laboratory examinations, and CT manifestations between the ordinary patients and the severe/critical patients. Many factors are related to the severity of the disease, which can help clinicians to judge the severity of the patient and evaluate the prognosis.
View Paper: https://www.semanticscholar.org/paper/56d76b6c456fcb1a082fed527f454284682e6b6b
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Citations in the corpus
- The Role of Imaging in the Detection and Management of COVID-19: A Review (2020, background): “Li et al. [31] investigated the chest CT findings and clinical features associated with severe and critical COVID-19 and found that CT scores differed significantly between severe/critical and typical patients (P < 0.001).”
- Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review (2020, background): “1b) with occurrence rate of 2~64% [12, 15, 23] .”