Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies.

By Z. Pang, Renee Raudonis, B. R. Glick, Tong-Jun Lin, Zhenyu Cheng. Biotechnology Advances, 2019

1,939 citations recorded by the source corpus.

Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Strains of Pseudomonas aeruginosa are known to utilize their high levels of intrinsic and acquired resistance mechanisms to counter most antibiotics. In addition, adaptive antibiotic resistance of P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections. The discovery and development of alternative therapeutic strategies that present novel avenues against P. aeruginosa infections are increasingly demanded and gaining more and more attention. Although mostly at the preclinical stages, many recent studies have reported several innovative therapeutic technologies that have demonstrated pronounced effectiveness in fighting against drug-resistant P. aeruginosa strains. This review highlights the mechanisms of antibiotic resistance in P. aeruginosa and discusses the current state of some novel therapeutic approaches for treatment of P. aeruginosa infections that can be further explored in clinical practice.

Subfields: Ecology, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/56a8f6844cdfcc1a4b3189b2342ddcab4122e9de

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In Ecology

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Citations in the corpus

• Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies (2021, background): “Biofilm formation contributes towards the development of antibiotic resistance and the formation of persistent cells which are responsible for the unmanageable persistence of microbial infections [5].”
• Bacterial Antibiotic Resistance: The Most Critical Pathogens (2021, background): “aeruginosa has shown intrinsic resistance to many antibiotics that is due to different mechanisms of resistance that are both intrinsic and acquired from other microorganisms [57,58].”
• Pseudomonas aeruginosa Biofilms (2020, neutral): “aeruginosa, thus increasing mortality [5].”
• Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics (2022, background): “aeruginosa depends primarily on multiple intrinsic and acquired antibiotic resistance mechanisms, including the biofilm-mediated formation of resistant and multi-drug-resistant persistent cells.(223) Therefore, P.”