Cytochrome P450s and other enzymes in drug metabolism and toxicity

By F. Guengerich. AAPS Journal, 2006

617 citations recorded by the source corpus.

Subfields: Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/5669c60dedd2e81aa1bc9d8e37dc4075c0359135

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Garima Sharma
2. C. Doss
3. Sang-Soo Lee
4. C. Chakraborty
5. M. Santacroce
6. G. Crescenzo
7. E. Casalino
8. O. Lai

Citations in the corpus

• Aflatoxins in aquatic species: metabolism, toxicity and perspectives (2008, background): “Once formed inside the cell, the exo-epoxide is sufficiently stable to migrate from the endoplasmic reticulum to the nucleus where it binds covalently to genetic material, inducing structural modifications and a spectrum of DNA lesions (Bailey et al. 1996; Guengerich 2006).”
• Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine (2017, background): “Drug-metabolizing enzymes, such as cytochrome P450 (CYP or P450) isoforms, play crucial roles in drug metabolism.(71) Drug transporters, including ABC and SLC transporters, also play key roles in drug absorption, distribution, and excretion.”