Electrical nanogap devices for biosensing

By Xing Chen, Zheng Guo, Guimei Yang, Jie Li, Minqiang Li, Jinhuai Liu, Xingjiu Huang. 2010

221 citations recorded by the source corpus.

For detecting substances that are invisible to the human eye or nose, and particularly those biomolecules, the devices must have very small feature sizes, be compact and provide a sufficient level of sensitivity, often to a small number of biomolecules that are just a few nanometres in size. Electrical nanogap devices for biosensing have emerged as a powerful technique for detecting very small quantities of biomolecules. The most charming feature of the devices is to directly transduce events of biomolecules specific binding into useful electrical signals such as resistance/impedance, capacitance/dielectric, or field-effect. Nanogap devices in electrical biosensing have become a busy area of research which is continually expanding. A wealth of research is available discussing planar and vertical nanogap devices for biosensing. Planar nanogap devices including label-free, gold nanoparticle-labeled, nanoparticles-enhanced, nanogapped gold particle film, and carbon nanotube nanogap devices as well as vertical nanogap devices with two and three terminals for biosensing are carefully reviewed. The aim of this paper is to provide an updated overview of the work in this field. In each part, we discuss the principles of operation of electrical biosensing and consider major strategies for enhancing their performance and/or key challenges and opportunities in current stages, and in their further development.

Subfields: Biomedical Engineering, Electrical and Electronic Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/56196ee43b39f054674d6ce2aa59ebaed21cbf48

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In Biomedical Engineering

In Electrical and Electronic Engineering

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Citations in the corpus

Electrochemical Impedance Spectroscopy (EIS): Principles, Construction, and Biosensing Applications (2021, background): “The distance limit of 300 nm was defined, since it characterizes the upper limit of the electrical double layer, which formed at all charged conductive sides in aqueous media [105,106].”
Performance Assessment of A Novel Vertical Dielectrically Modulated TFET-Based Biosensor (2017, methodology): “THE field-effect transistor (FET)-based biosensors are very popular for label-free detection process and also compatible for the CMOS technology [1]–[4].”
A Dielectric-Modulated Tunnel-FET-Based Biosensor for Label-Free Detection: Analytical Modeling Study and Sensitivity Analysis (2012, methodology): “A LOT OF RESEARCH interest has been shown in the area of field-effect transistor (FET)-based biosensors due to the advantages that they offer in terms of being compatible with the standard CMOS technology, miniaturization, costeffective mass production, and label-free detection process [1].”