Mechanisms of Disease: astrocytes in neurodegenerative disease
By N. Maragakis, Jeffrey D. Rothstein. Nature Clinical Practice Neurology, 2006
821 citations recorded by the source corpus.
Subfields: Neurology, Physiology
View Paper: https://www.semanticscholar.org/paper/55db48575a68edfaa9161c288dbea2780255c0a4
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Citations in the corpus
- Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “The concept of reactive astrogliosis and its molecular and cellular definition is still incomplete, and we are only starting to understand its multifaceted functions in disease pathogenesis and in the process of recovery from CNS injuries (17, 34, 52, 146, 210, 221) (FIGURE 1).”
- STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury (2008, background): “Nevertheless, it is important to note that although reactive astrocyte activities can in some cases be associated with restricting inflammation, limiting lesion size and preserving function (Sofroniew, 2005; Maragakis and Rothstein, 2006; Li et al., 2008), astrocytes also respond to signaling pathwa”
- Astrocytes: biology and pathology (2009, background): “There is increasing investigation of the potential for astrocytes contributions to dysfunction and degeneration in Huntington’s disease through disturbances in glutamate uptake that can alter synaptic function and lead to excitotoxicity, or through abnormal production of neurotoxic molecules [127, 1”
- Microglia in Alzheimer’s disease (2018, background): “Microgliosis and astrogliosis are common features of many neurodegenerative diseases with distinct etiologies (Maragakis and Rothstein, 2006; Ransohoff and Perry, 2009; Glass et al., 2010), but it was uncertain whether these histopathological changes reflect a beneficial, detrimental, or inconsequen”