Cdk1 is sufficient to drive the mammalian cell cycle

By David Santamaría, C. Barrière, Antonio Cerqueira, S. Hunt, Claudine Tardy, K. Newton, J. Cáceres, P. Dubus, Marcos Malumbres, M. Barbacid. Nature, 2007

1,071 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/55d3b78e945a6a913add83a212bf290863285f72

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Philipp Kaldis
2. Marcos Malumbres
3. A. Satyanarayana

In Molecular Biology

1. Philipp Kaldis
2. Marcos Malumbres
3. J. León
4. A. Satyanarayana
5. G. Bretones
6. M. Delgado

In Oncology

1. Philipp Kaldis
2. Marcos Malumbres
3. A. Satyanarayana

Citations in the corpus

• Myc and cell cycle control. (2015, background): “Moreover, concomitant loss of the genes of interphase Cdk does not result in a general disturbance of the cell cycle in most cell types, Cdk1 alone being sufficient to drive the cell cycle [2,21].”
• Cyclin-dependent kinases (2014, background): “Like its yeast ortholog, Cdk1 is the only CDK essential for the cell cycle in mammals [9], whereas both Cdk2 and Cdk3 are dispensable [3,10].”
• Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms (2009, background): “In accordance with this hypothesis, it was observed that deletion of Cdk1 (our unpublished results) or a gene trap mutation in the Cdk1 gene (Santamaria et al., 2007) led to early embryonic lethality and the embryos fail to reach even the blastocyst stage in the absence of Cdk1.”