Intracellular Organic Osmolytes: Function and Regulation*

By M. Burg, J. Ferraris. Journal of Biological Chemistry, 2008

600 citations recorded by the source corpus.

Cells of almost all organisms accumulate organic osmolytes when exposed to hyperosmolality, most often in the form of high salt or urea. In this review, we discuss 1) how the organic osmolytes protect; 2) the identity of osmolytes in Archaea, bacteria, yeast, plants, marine animals, and mammals; 3) the mechanisms by which they are accumulated; 4) sensors of osmolality; 5) the signaling pathways involved; and 6) mutual counteraction by urea and methylamines.

Subfields: Cell Biology, Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/55738bb5da54f81fdebb225c49e88feb851ec19b

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In Molecular Biology

1. M. Kaushal
2. Suhas P. Wani

Citations in the corpus

• Rhizobacterial-plant interactions: Strategies ensuring plant growth promotion under drought and salinity stress (2016, background): “Trehalose synthesis and accumulation occurs in absence of organic osmolytes however glycine betaine and proline are accumulated preferentially by uptake (Burg and Ferraris, 2008).”